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KMID : 0881720200350060567
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Journal of Food Hygiene and Safety
2020 Volume.35 No. 6 p.567 ~ p.573
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Genotoxicity Study of Immature Green Persimmon Extract
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Ham Young-Min
Yoon Seon-A
Hyun Ho-Bong
Go Bo-Ram
Jung Yong-Hwan
Oh Dae-Ju
Yoon Weon-Jong
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Abstract
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The persimmon is commonly cultivated in temperate regions of the world, including China,Korea, Japan, Brazil, Turkey, and Italy. In some Asian cultures, consumers are aware of the health claims related tothe persimmon and its functional ingredients. The rich phytochemistry of the persimmon has opened new avenues ofresearch on diet-based regimens designed to cure various ailments. This study was conducted to identify the genotoxicityof immature green persimmon (Diospyros kaki THUNB.) extract (DKA). The bacterial reverse mutation assay,the chromosomal aberration assay, and the mammalian micronucleus test were performed to determine the DKAgenotoxicity. The result of the bacterial reverse mutation assay revealed that the DKA did not induce mutagenicity inSalmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA with or without metabolicactivation of S9 mixture. The oral administration of DKA also caused no significant increase in the number of micronucleatedpolychromatic erythrocytes or in the mean ratio of polychromatic to total erythrocytes. In addition, DKAdid not cause a significant chromosome aberration on CHL cells in the presence or absence of S9 activation. In conclusion,DKA could be considered as a reliable and safe functional food since no toxicity was found under the conditionof this study.
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KEYWORD
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Immature persimmon, Genotoxicity, Reverse mutation, Micronucleus formation, Chromosome aberration
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